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DCフィールド | 値 | 言語 |
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dc.contributor.author | Satou, Yutaka | en |
dc.contributor.author | Imai, Kaoru S. | en |
dc.contributor.author | Satoh, Nori | en |
dc.contributor.alternative | 佐藤, ゆたか | ja |
dc.contributor.alternative | 今井, 薫 | ja |
dc.contributor.alternative | 佐藤, 矩行 | ja |
dc.date.accessioned | 2024-05-20T04:52:02Z | - |
dc.date.available | 2024-05-20T04:52:02Z | - |
dc.date.issued | 2004-06 | - |
dc.identifier.uri | http://hdl.handle.net/2433/287629 | - |
dc.description.abstract | Understanding the molecular basis of heart development is an important research area, because malformation of the cardiovascular system is among the most frequent inborn defects. Although recent research has identified molecules responsible for heart morphogenesis in vertebrates, the initial specification of heart progenitors has not been well characterized. Ascidians provide an appropriate experimental system for exploring this specification mechanism, because the lineage for the juvenile heart is well characterized, with B7.5 cells at the 110-cell stage giving rise to embryonic trunk ventral cells (TVCs) or the juvenile heart progenitors. Here, we show that Cs-Mesp, the sole ortholog of vertebrate Mesp genes in the ascidian Ciona savignyi, is specifically and transiently expressed in the embryonic heart progenitor cells (B7.5 cells). Cs-Mesp is essential for the specification of heart precursor cells, in which Nkx, HAND and HAND-like (NoTrlc) genes are expressed. As a result, knockdown of Cs-Mesp with specific morpholino antisense oligonucleotides causes failure of the development of the juvenile heart. Together with previous evidence obtained in mice, the present results suggest that a mechanism for heart specification beginning with Mespthrough Nkx and HAND is conserved among chordates. | en |
dc.language.iso | eng | - |
dc.publisher | The Company of Biologists | en |
dc.rights | © 2004. Published by The Company of Biologists Ltd | en |
dc.rights | The full-text file will be made open to the public on 2 June 2005 in accordance with publisher's 'Terms and Conditions for Self-Archiving' | en |
dc.subject | Chordate | en |
dc.subject | Ciona savignyi | en |
dc.subject | Mesp | en |
dc.subject | Heart development | en |
dc.title | The ascidian Mesp gene specifies heart precursor cells | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Development | en |
dc.identifier.volume | 131 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 2533 | - |
dc.identifier.epage | 2541 | - |
dc.relation.doi | 10.1242/dev.01145 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 15115756 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2005-06-02 | - |
datacite.awardNumber | 14704070 | - |
datacite.awardNumber | 13044001 | - |
datacite.awardNumber | 03J04751 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14704070/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13044001/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03J04751/ | - |
dc.identifier.pissn | 0950-1991 | - |
dc.identifier.eissn | 1477-9129 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | ホヤ胚の内胚葉分化と中胚葉誘導における分子機構の解明 | ja |
jpcoar.awardTitle | 発生システムの構造と進化のメカニズム | ja |
jpcoar.awardTitle | ユウレイボヤにおける中胚葉誘導の分子メカニズムの解析 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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