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DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Umemura, Keisuke | en |
dc.contributor.author | Katada, Yoshiki | en |
dc.contributor.author | Nakagawa, Shunsaku | en |
dc.contributor.author | Hira, Daiki | en |
dc.contributor.author | Yutaka, Yojiro | en |
dc.contributor.author | Tanaka, Satona | en |
dc.contributor.author | Ohsumi, Akihiro | en |
dc.contributor.author | Nakajima, Daisuke | en |
dc.contributor.author | Date, Hiroshi | en |
dc.contributor.author | Nagao, Miki | en |
dc.contributor.author | Terada, Tomohiro | en |
dc.contributor.alternative | 梅村, 圭祐 | ja |
dc.contributor.alternative | 片田, 佳希 | ja |
dc.contributor.alternative | 中川, 俊作 | ja |
dc.contributor.alternative | 平, 大樹 | ja |
dc.contributor.alternative | 豊, 洋次郎 | ja |
dc.contributor.alternative | 田中, 里奈 | ja |
dc.contributor.alternative | 大角, 明宏 | ja |
dc.contributor.alternative | 中島, 大輔 | ja |
dc.contributor.alternative | 伊達, 洋至 | ja |
dc.contributor.alternative | 長尾, 美紀 | ja |
dc.contributor.alternative | 寺田, 智祐 | ja |
dc.date.accessioned | 2024-06-19T00:29:28Z | - |
dc.date.available | 2024-06-19T00:29:28Z | - |
dc.date.issued | 2024-08 | - |
dc.identifier.uri | http://hdl.handle.net/2433/287857 | - |
dc.description.abstract | Introduction: Fungal infection after lung transplantation can lead to poor clinical outcome, for which lung transplant recipients require prophylaxis. One of the antifungal agents used after lung transplantation is nebulized amphotericin B (AMB). Nebulized AMB causes adverse events such as dyspnea and airway irritation, and long-term use leads to high economic costs. So far, prophylactic regimens employing AMB deoxycholate (AMB-d) and liposomal AMB (L-AMB) have been developed. This study compared the efficacy, safety, and cost of AMB-d and L-AMB. Patients and methods: Patients who underwent lung transplantation at Kyoto University Hospital from January 2021 to May 2023 were included in this study. Thirty-three patients received nebulized AMB-d, whereas 29 received nebulized L-AMB. Results: Both regimens maintained comparable prophylactic efficacy regarding the development of fungal infection in the AMB-d and L-AMB groups (3.0% vs. 3.4%, P = 0.877). Patients treated with nebulized L-AMB experienced fewer respiratory-related adverse reactions than those treated with nebulized AMB-d (6.9% vs. 30.3%, P < 0.05), leading to a longer treatment duration with L-AMB than with AMB-d. Additionally, the daily cost of administering L-AMB was lower than that of administering AMB-d (3609 Japanese yen vs. 1792.3 Japanese yen, P < 0.05). Discussion: These results suggest that nebulized L-AMB is safer and more cost-effective than nebulized AMB-d, with comparable efficacy. | en |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. | en |
dc.rights | The full-text file will be made open to the public on 1 August 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | Nebulized liposomal amphotericin B | en |
dc.subject | Nebulized amphotericin B deoxycholate | en |
dc.subject | Lung transplantation | en |
dc.subject | Fungal prophylaxis | en |
dc.subject | Pharmacoeconomics | en |
dc.title | Comparison of the safety and cost-effectiveness of nebulized liposomal amphotericin B and amphotericin B deoxycholate for antifungal prophylaxis after lung transplantation | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Journal of Infection and Chemotherapy | en |
dc.identifier.volume | 30 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 741 | - |
dc.identifier.epage | 745 | - |
dc.relation.doi | 10.1016/j.jiac.2024.02.010 | - |
dc.textversion | author | - |
dc.identifier.pmid | 38354908 | - |
dcterms.accessRights | embargoed access | - |
datacite.date.available | 2025-08-01 | - |
dc.identifier.pissn | 1341-321X | - |
dc.identifier.eissn | 1437-7780 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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