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DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Ishida, Tasuku | en |
dc.contributor.author | Satou, Yutaka | en |
dc.contributor.alternative | 石田, 祐 | ja |
dc.contributor.alternative | 佐藤, ゆたか | ja |
dc.date.accessioned | 2024-06-27T05:45:46Z | - |
dc.date.available | 2024-06-27T05:45:46Z | - |
dc.date.issued | 2024-06 | - |
dc.identifier.uri | http://hdl.handle.net/2433/287891 | - |
dc.description | 脊椎動物らしさをつくる細胞群の進化的起源--脊椎動物にもっとも近縁なホヤから探る--京都大学プレスリリース. 2024-04-04. | ja |
dc.description.abstract | Neural-crest cells and neuromesodermal progenitors (NMPs) are multipotent cells that are important for development of vertebrate embryos. In embryos of ascidians, which are the closest invertebrate relatives of vertebrates, several cells located at the border between the neural plate and the epidermal region have neural-crest-like properties; hence, the last common ancestor of ascidians and vertebrates may have had ancestral cells similar to neural-crest cells. However, these ascidian neural-crest-like cells do not produce cells that are commonly of mesodermal origin. Here we showed that a cell population located in the lateral region of the neural plate has properties resembling those of vertebrate neural-crest cells and NMPs. Among them, cells with Tbx6-related expression contribute to muscle near the tip of the tail region and cells with Sox1/2/3 expression give rise to the nerve cord. These observations and cross-species transcriptome comparisons indicate that these cells have properties similar to those of NMPs. Meanwhile, transcription factor genes Dlx.b, Zic-r.b and Snai, which are reminiscent of a gene circuit in vertebrate neural-crest cells, are involved in activation of Tbx6-related.b. Thus, the last common ancestor of ascidians and vertebrates may have had cells with properties of neural-crest cells and NMPs and such ancestral cells may have produced cells commonly of ectodermal and mesodermal origins. | en |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | en |
dc.rights | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41559-024-02387-8 | en |
dc.rights | The full-text file will be made open to the public on 02 October 2024 in accordance with publisher's 'Terms and Conditions for Self-Archiving' | en |
dc.rights | This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | en |
dc.subject | Developmental biology | en |
dc.subject | Evolutionary developmental biology | en |
dc.title | Ascidian embryonic cells with properties of neural-crest cells and neuromesodermal progenitors of vertebrates | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Nature Ecology & Evolution | en |
dc.identifier.volume | 8 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 1154 | - |
dc.identifier.epage | 1164 | - |
dc.relation.doi | 10.1038/s41559-024-02387-8 | - |
dc.textversion | author | - |
dc.address | Department of Zoology, Graduate School of Science, Kyoto University | en |
dc.address | Department of Zoology, Graduate School of Science, Kyoto University | en |
dc.identifier.pmid | 38565680 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2024-04-04 | - |
dcterms.accessRights | embargoed access | - |
datacite.date.available | 2024-10-02 | - |
datacite.awardNumber | 21H02486 | - |
datacite.awardNumber | 21H05239 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02486/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-21H05239 | - |
dc.identifier.eissn | 2397-334X | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | ホヤ初期胚の細胞運命決定機構 | ja |
jpcoar.awardTitle | 適応回路の基本設計の構築メカニズム | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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