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タイトル: Synchronized Expansion and Contraction of Olfactory, Vomeronasal, and Taste Receptor Gene Families in Hystricomorph Rodents
著者: Niimura, Yoshihito
Biswa, B, Bhim
Kishida, Takushi
Toyoda, Atsushi
Fujiwara, Kazumichi
Ito, Masato
Touhara, Kazushige
Inoue-Murayama, Miho
Jenkins, H, Scott
Adenyo, Christopher
Kayang, B, Boniface
Koide, Tsuyoshi
著者名の別形: 新村, 芳人
岸田, 拓士
豊田, 敦
藤原, 一道
伊藤, 正人
東原, 和成
村山, 美穂
小出, 剛
キーワード: olfactory receptor
vomeronasal receptor
taste receptor
multigene family
pheromone
hystricomorph rodents
発行日: Apr-2024
出版者: Oxford University Press (OUP)
Society for Molecular Biology and Evolution
誌名: Molecular Biology and Evolution
巻: 41
号: 4
論文番号: msae071
抄録: Chemical senses, including olfaction, pheromones, and taste, are crucial for the survival of most animals. There has long been a debate about whether different types of senses might influence each other. For instance, primates with a strong sense of vision are thought to have weakened olfactory abilities, although the oversimplified trade-off theory is now being questioned. It is uncertain whether such interactions between different chemical senses occur during evolution. To address this question, we examined four receptor gene families related to olfaction, pheromones, and taste: olfactory receptor (OR), vomeronasal receptor type 1 and type 2 (V1R and V2R), and bitter taste receptor (T2R) genes in Hystricomorpha, which is morphologically and ecologically the most diverse group of rodents. We also sequenced and assembled the genome of the grasscutter, Thryonomys swinderianus. By examining 16 available genome assemblies alongside the grasscutter genome, we identified orthologous gene groups among hystricomorph rodents for these gene families to separate the gene gain and loss events in each phylogenetic branch of the Hystricomorpha evolutionary tree. Our analysis revealed that the expansion or contraction of the four gene families occurred synchronously, indicating that when one chemical sense develops or deteriorates, the others follow suit. The results also showed that V1R/V2R genes underwent the fastest evolution, followed by OR genes, and T2R genes were the most evolutionarily stable. This variation likely reflects the difference in ligands of V1R/V2Rs, ORs, and T2Rs: species-specific pheromones, environment-based scents, and toxic substances common to many animals, respectively.
記述: ヤマアラシ亜目における嗅覚・フェロモン・味覚受容体遺伝子の同調的進化~グルメな動物は鼻も良い!?~.京都大学プレスリリース. 2024-04-23.
著作権等: © The Author(s) 2024. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2433/287951
DOI(出版社版): 10.1093/molbev/msae071
PubMed ID: 38649162
関連リンク: https://www.kyoto-u.ac.jp/ja/research-news/2024-04-23
出現コレクション:学術雑誌掲載論文等

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