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j.isci.2024.111565.pdf | 7.5 MB | Adobe PDF | 見る/開く |
タイトル: | Transcriptomic landscape of hyperthyroidism in mice overexpressing thyroid-Stimulating hormone |
著者: | Yamauchi, Ichiro ![]() ![]() ![]() Sugawa, Taku Hakata, Takuro Yoshizawa, Akira Kita, Tomoko ![]() ![]() ![]() Kishimoto, Yo Kimura, Sadahito Sakurai, Aya Kosugi, Daisuke Fujita, Haruka Okamoto, Kentaro Ueda, Yohei ![]() ![]() Fujii, Toshihito Taura, Daisuke ![]() ![]() Sakane, Yoriko Yasoda, Akihiro Inagaki, Nobuya |
著者名の別形: | 山内, 一郎 須川, 琢 伯田, 琢郎 吉澤, 亮 喜多, 知子 岸本, 曜 木村, 貞仁 櫻井, 絢 小杉, 大輔 藤田, 晴香 岡本, 健太郎 植田, 洋平 藤井, 寿人 田浦, 大輔 坂根, 依利子 八十田, 明宏 稲垣, 暢也 |
キーワード: | Endocrine system physiology Endocrinology Transcriptomics Model organism |
発行日: | 17-Jan-2025 |
出版者: | Elsevier BV |
誌名: | iScience |
巻: | 28 |
号: | 1 |
論文番号: | 111565 |
抄録: | Activation of thyroid-stimulating hormone receptor (TSHR) fundamentally leads to hyperthyroidism. To elucidate TSHR signaling, we conducted transcriptome analyses for hyperthyroid mice that we generated by overexpressing TSH. TSH overexpression drastically changed their thyroid transcriptome. In particular, enrichment analyses identified the cell cycle, phosphatidylinositol 3-kinase/Akt pathway, and Ras-related protein 1 pathway as possibly associated with goiter development. Regarding hyperthyroidism, Slc26a4 was exclusively upregulated with TSH overexpression among genes crucial to thyroid hormone secretion. To verify its significance, we overexpressed TSH in Slc26a4 knockout mice. TSH overexpression caused hyperthyroidism in Slc26a4 knockout mice, equivalent to that in control mice. Thus, we did not observe significant changes in known genes and pathways involved in thyroid hormone secretion with TSH overexpression. Our datasets might include candidate genes that have not yet been identified as regulators of thyroid function. Our transcriptome datasets regarding hyperthyroidism can contribute to future research on TSHR signaling. |
記述: | バセドウ病の新たな治療法開発を目指して --独自モデルマウスによる甲状腺機能亢進症研究--. 京都大学プレスリリース. 2024-12-16. |
著作権等: | © 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license. |
URI: | http://hdl.handle.net/2433/290943 |
DOI(出版社版): | 10.1016/j.isci.2024.111565 |
PubMed ID: | 39811643 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2024-12-16 |
出現コレクション: | 学術雑誌掲載論文等 |

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