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タイトル: | Neural substrates underlying distinct dual cognitive syndromes in Parkinson's disease |
著者: | Yoshimura, Kenji Shima, Atsushi ![]() ![]() ![]() Kambe, Daisuke Furukawa, Koji Nishida, Akira Wada, Ikko Sakato, Yusuke Sakamaki-Tsukita, Haruhi Terada, Yuta Yamakado, Hodaka ![]() ![]() Taruno, Yosuke Nakanishi, Etsuro Sawamura, Masanori Fujimoto, Koji ![]() ![]() ![]() Fushimi, Yasutaka ![]() ![]() ![]() Okada, Tomohisa Nakamoto, Yuji Hanakawa, Takashi ![]() ![]() ![]() Takahashi, Ryosuke ![]() ![]() ![]() Sawamoto, Nobukatsu ![]() ![]() |
著者名の別形: | 吉村, 賢二 島, 淳 神辺, 大輔 古川, 公嗣 西田, 聖 和田, 一孝 坂戸, 勇介 酒巻-月田, 春日 寺田, 裕太 山門, 穂高 樽野, 陽亮 中西, 悦郎 澤村, 正典 藤本, 晃司 伏見, 育崇 岡田, 知久 中本, 裕士 花川, 隆 髙橋, 良輔 澤本, 伸克 |
キーワード: | [¹²³I]FP-CIT SPECT 7T-MRI mild cognitive impairment Parkinson's disease surface-based morphometry |
発行日: | Jan-2025 |
出版者: | Wiley European Academy of Neurology |
誌名: | European Journal of Neurology |
巻: | 32 |
号: | 1 |
論文番号: | e70022 |
抄録: | Background: A dual-syndrome hypothesis, which states the cognitive impairments in Parkinson's disease (PD) are attributable to frontostriatal dopaminergic dysregulation and cortical disturbance-each associated with attention/executive and memory/visuospatial dysfunction, respectively-has been widely accepted. This multisystem contribution also underlies highly heterogeneous progression rate to dementia. Methods: Nondemented PD patients who underwent [¹²³I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ([¹²³I]FP-CIT) SPECT and neuropsychological examinations were enrolled. Patients who agreed to participate and age- and sex-matched healthy controls (HCs) also underwent 7-T MRI. Patients were classified as cognitively normal (PD-CN) or mild cognitive impairment (PD-MCI) following the level II criteria of Movement Disorder Society Guideline. Results: A total of 155 patients (PD-CN/PD-MCI 74/81) were enrolled, whereas 76 patients (PD-CN/PD-MCI 35/41) and 56 HCs underwent 7 T-MRI. The caudate [¹²³I]FP-CIT uptake in PD was correlated with the performance of attention/working memory (trail-making test [TMT]-A and symbol digit modality test) and executive (TMT-B) domains. In contrast, the regional cortical thickness in the left frontotemporal and right frontal lobes in PD was correlated with performance of memory (Hopkins verbal learning test-revised delayed recall) and visuospatial (judgment of line orientation) domains. Moreover, compared to 37 HCs with a Montreal Cognitive Assessment score of >25, PD-CN patients showed broad occipitoparietal cortical thinning. Conclusions: We demonstrated distinctive impairments of dopaminergic frontostriatal deficits and cortical degeneration as neural bases for the dual-syndrome hypothesis. Our findings suggest that occipitoparietal lobe thinning occurs at a cognitively normal stage, and additional frontotemporal lobe thinning underlies impairments in the memory and visuospatial domains at the PD-MCI stage. |
記述: | パーキンソン病患者の認知機能低下における複数の神経基盤の解明. 京都大学プレスリリース. 2024-12-27. |
著作権等: | © 2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
URI: | http://hdl.handle.net/2433/291063 |
DOI(出版社版): | 10.1111/ene.70022 |
PubMed ID: | 39716907 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2024-12-27-0 |
出現コレクション: | 学術雑誌掲載論文等 |

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