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タイトル: Neural substrates underlying distinct dual cognitive syndromes in Parkinson's disease
著者: Yoshimura, Kenji
Shima, Atsushi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-3068-4621 (unconfirmed)
Kambe, Daisuke
Furukawa, Koji
Nishida, Akira
Wada, Ikko
Sakato, Yusuke
Sakamaki-Tsukita, Haruhi
Terada, Yuta
Yamakado, Hodaka  kyouindb  KAKEN_id
Taruno, Yosuke
Nakanishi, Etsuro
Sawamura, Masanori
Fujimoto, Koji  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-1209-7949 (unconfirmed)
Fushimi, Yasutaka  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1982-3168 (unconfirmed)
Okada, Tomohisa
Nakamoto, Yuji
Hanakawa, Takashi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-3267-8214 (unconfirmed)
Takahashi, Ryosuke  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1407-9640 (unconfirmed)
Sawamoto, Nobukatsu  kyouindb  KAKEN_id
著者名の別形: 吉村, 賢二
島, 淳
神辺, 大輔
古川, 公嗣
西田, 聖
和田, 一孝
坂戸, 勇介
酒巻-月田, 春日
寺田, 裕太
山門, 穂高
樽野, 陽亮
中西, 悦郎
澤村, 正典
藤本, 晃司
伏見, 育崇
岡田, 知久
中本, 裕士
花川, 隆
髙橋, 良輔
澤本, 伸克
キーワード: [¹²³I]FP-CIT SPECT
7T-MRI
mild cognitive impairment
Parkinson's disease
surface-based morphometry
発行日: Jan-2025
出版者: Wiley
European Academy of Neurology
誌名: European Journal of Neurology
巻: 32
号: 1
論文番号: e70022
抄録: Background: A dual-syndrome hypothesis, which states the cognitive impairments in Parkinson's disease (PD) are attributable to frontostriatal dopaminergic dysregulation and cortical disturbance-each associated with attention/executive and memory/visuospatial dysfunction, respectively-has been widely accepted. This multisystem contribution also underlies highly heterogeneous progression rate to dementia. Methods: Nondemented PD patients who underwent [¹²³I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ([¹²³I]FP-CIT) SPECT and neuropsychological examinations were enrolled. Patients who agreed to participate and age- and sex-matched healthy controls (HCs) also underwent 7-T MRI. Patients were classified as cognitively normal (PD-CN) or mild cognitive impairment (PD-MCI) following the level II criteria of Movement Disorder Society Guideline. Results: A total of 155 patients (PD-CN/PD-MCI 74/81) were enrolled, whereas 76 patients (PD-CN/PD-MCI 35/41) and 56 HCs underwent 7 T-MRI. The caudate [¹²³I]FP-CIT uptake in PD was correlated with the performance of attention/working memory (trail-making test [TMT]-A and symbol digit modality test) and executive (TMT-B) domains. In contrast, the regional cortical thickness in the left frontotemporal and right frontal lobes in PD was correlated with performance of memory (Hopkins verbal learning test-revised delayed recall) and visuospatial (judgment of line orientation) domains. Moreover, compared to 37 HCs with a Montreal Cognitive Assessment score of >25, PD-CN patients showed broad occipitoparietal cortical thinning. Conclusions: We demonstrated distinctive impairments of dopaminergic frontostriatal deficits and cortical degeneration as neural bases for the dual-syndrome hypothesis. Our findings suggest that occipitoparietal lobe thinning occurs at a cognitively normal stage, and additional frontotemporal lobe thinning underlies impairments in the memory and visuospatial domains at the PD-MCI stage.
記述: パーキンソン病患者の認知機能低下における複数の神経基盤の解明. 京都大学プレスリリース. 2024-12-27.
著作権等: © 2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
URI: http://hdl.handle.net/2433/291063
DOI(出版社版): 10.1111/ene.70022
PubMed ID: 39716907
関連リンク: https://www.kyoto-u.ac.jp/ja/research-news/2024-12-27-0
出現コレクション:学術雑誌掲載論文等

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