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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| s42003-025-07549-3.pdf | 2.59 MB | Adobe PDF | 見る/開く |
| タイトル: | Substrates, regulation, cellular functions, and disease associations of P4-ATPases |
| 著者: | Shin, Hye-Won Takatsu, Hiroyuki |
| 著者名の別形: | 申, 惠媛 高津, 宏之 |
| キーワード: | Mechanisms of disease Membrane curvature |
| 発行日: | 28-Jan-2025 |
| 出版者: | Springer Nature |
| 誌名: | Communications Biology |
| 巻: | 8 |
| 論文番号: | 135 |
| 抄録: | P4-ATPases, a subfamily of the P-type ATPase superfamily, play a crucial role in translocating membrane lipids from the exoplasmic/luminal leaflet to the cytoplasmic leaflet. This process generates and regulates transbilayer lipid asymmetry. These enzymes are conserved across all eukaryotes, and the human genome encodes 14 distinct P4-ATPases. Initially identified as aminophospholipid translocases, P4-ATPases have since been found to translocate other phospholipids, including phosphatidylcholine, phosphatidylinositol, and even glycosphingolipids. Recent advances in structural analysis have significantly improved our understanding of the lipid transport machinery associated with P4-ATPases, as documented in recent reviews. In this review, we highlight the emerging evidence related to substrate diversity, the regulation of cellular localization, enzymatic activities, and their impact on organism homeostasis and diseases. |
| 著作権等: | This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s CreativeCommons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. © The Author(s) 2025 |
| URI: | http://hdl.handle.net/2433/291782 |
| DOI(出版社版): | 10.1038/s42003-025-07549-3 |
| PubMed ID: | 39875509 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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