Glioblastoma with markedly reduced contrast enhancement after corticosteroid administration: Increased density and reduced diffusion capability are noteworthy

Abstract

Corticosteroids are widely used to manage peritumoral edema and associated neurological deficits in patients with brain tumors. We describe the case of a 71-year-old male patient with glioblastoma in which contrast enhancement decreased on radiographic imaging following corticosteroid administration, which has been reported previously in only 9 cases. This report aims to discuss radiographic changes in glioblastoma (density on computed tomography and diffusion capability on diffusion-weighted magnetic resonance imaging, in addition to enhancement on contrast-enhanced T1-weighted magnetic resonance imaging) following steroid administration and also following steroid discontinuation.