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タイトル: | Elucidation of conformational hysteresis on a giant DNA |
著者: | Shew, Chwen-Yang Higuchi, Yuji Yoshikawa, Kenichi |
キーワード: | DNA hysteresis molecular biophysics molecular configurations |
発行日: | 28-Aug-2007 |
出版者: | American Institute of Physics |
引用: | C.-Y. Shew, Y. Higuchi, and K. Yoshikawa “Elucidation of conformational hysteresis on a giant DNA”, J. Chem. Phys., 127, 085103 (2007) |
誌名: | Journal of Chemical Physics |
巻: | 127 |
論文番号: | 085103 |
抄録: | The conformational behavior of a giant DNA mediated by condensing agents in the bulk solution has been investigated through experimental and theoretical approaches. Experimentally, a pronounced conformational hysteresis is observed for folding and unfolding processes, by increasing and decreasing the concentration of condensing agent (polyethylene glycol) (PEG), respectively. To elucidate the observed hysteresis, a semiflexible chain model is studied by using Monte Carlo simulations for the coil-globule transition. In the simulations, the hysteresis loop emerges for stiff enough chains, indicating distinct pathways for folding and unfolding processes. Also, our results show that globular state is thermodynamically more stable than coiled state in the hysteresis loop. Our findings suggest that increasing chain stiffness may reduce the chain conformations relevant to the folding pathway, which impedes the folding process. ©2007 American Institute of Physics |
著作権等: | Copyright (2007) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. |
URI: | http://hdl.handle.net/2433/45695 |
DOI(出版社版): | 10.1063/1.2759925 |
PubMed ID: | 17764302 |
出現コレクション: | 学術雑誌掲載論文等 |
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