The effect of pressure and temperature on the base-catalyzed condensation of cyclohexanone (The co-operative researches on the fundamental studies of the liquid phase reactions at high pressures)

Abstract

The base-catalyzed condensation of cyclohexanone to ketol in ethanol solution has been kinetically investigated in the range 0.68～9.75℃ and 1～2, 000kg/cm^2. The activation energy and entropy at 1 atm are 12.7 kcal/mole and -33.1cal/deg・mole, which are both quite close to the results in the absence of the solvent. The activation volume is -7.4cm^3/mole at 0.68℃ and -7.8 cm^3/mole at 9.75℃. From these results, it may be reasonably concluded that the transition state is not so much polar and the acceleration of a reaction can be mainly attributed to the structural effect.