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Title: How are small ions involved in the compaction of DNA molecules?
Authors: Iwaki, Takafumi
Saito, Takuya  kyouindb  KAKEN_id
Yoshikawa, Kenichi
Author's alias: 吉川, 研一
Keywords: DNA
Folding transition
Single-chain conformations
Salt effect
Issue Date: Apr-2007
Publisher: Elsevier
Citation: T. Iwaki, T. Saito, K. Yoshikawa, “How are small ions involved in the compaction of DNA molecules? ”, Colloids and Surfaces B: Biointerfaces, 56,126-133 (2007)
Journal title: Colloids and Surfaces B: Biointerfaces
Volume: 56
Issue: 1-2
Start page: 126
End page: 133
Abstract: DNA is a genetic material found in all life on Earth. DNA is composed of four types of nucleotide subunits, and forms a double-helical one-dimensional polyelectrolyte chain. If we focus on the microscopic molecular structure, DNA is a rigid rod-like molecule. On the other hand, with coarse graining, a long-chain DNA exhibits fluctuating behavior over the whole molecule due to thermal fluctuation. Owe to its semiflexible nature, individual giant DNA molecule undergoes a large discrete transition in the higher-order structure. In this folding transition into a compact state, small ions in the solution have a critical effect, since DNA is highly charged. In the present article, we interpret the characteristic features of DNA compaction while paying special attention to the role of small ions, in relation to a variety of single-chain morphologies generated as a result of compaction.
Rights: Copyright © 2006 Elsevier B.V. All rights reserved.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1016/j.colsurfb.2006.10.040
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