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Title: Real-time imaging of the somite segmentation clock: Revelation of unstable oscillators in the individual presomitic mesoderm cells
Authors: Masamizu, Yoshito
Ohtsuka, Toshiyuki  kyouindb  KAKEN_id
Takashima, Yoshiki
Nagahara, Hiroki
Takenaka, Yoshiko
Yoshikawa, Kenichi
Okamura, Hitoshi
Kageyama, Ryoichiro  kyouindb  KAKEN_id
Author's alias: 吉川, 研一
Issue Date: Jan-2006
Publisher: National Academy of Sciences
Citation: Y. Masamizu, T. Ohtsuka, Y. Takashima, H. Nagahara, Y. Takenaka, K. Yoshikawa, H. Okamura, and R. Kageyama, “Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells”, Proc. Natl. Acad. Sci. USA, 103, 1313-1318 (2006).
Journal title: PNAS : proceedings of the National Academy of Sciences of the United States of America
Volume: 103
Issue: 5
Start page: 1313
End page: 1318
Abstract: Expression of the bHLH gene Hes1 oscillates stably in the presomitic mesoderm (PSM) while transiently in other cells, suggesting that the Hes1 oscillators in the former and the latter could be intrinsically different. Real-time bioluminescence imaging of Hes1 expression showed that the Hes1 oscillation is robust and stable in the PSM while unstable in most individual fibroblasts and dissociated PSM cells. Thus, the Hes1 oscillators in individual PSM cells and fibroblasts are intrinsically similar, and these results, together with mathematical simulation, suggest that the cell-cell communication is essential not only for synchronization but also for stabilization of cellular oscillators.
Rights: Copyright © 2006 by the National Academy of Sciences
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/49175
DOI(Published Version): 10.1073/pnas.0508658103
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