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| Yoshikawa346.pdf | 5.1 MB | Adobe PDF | 見る/開く |
| タイトル: | Real-time imaging of the somite segmentation clock: Revelation of unstable oscillators in the individual presomitic mesoderm cells |
| 著者: | Masamizu, Yoshito Ohtsuka, Toshiyuki Takashima, Yoshiki Nagahara, Hiroki Takenaka, Yoshiko Yoshikawa, Kenichi Okamura, Hitoshi Kageyama, Ryoichiro  |
| 著者名の別形: | 正水, 芳人 大塚, 俊之 高嶋, 良樹 長原, 寛樹 武仲, 能子 吉川, 研一 影山, 龍一郎 |
| 発行日: | 31-Jan-2006 |
| 出版者: | National Academy of Sciences |
| 引用: | Y. Masamizu, T. Ohtsuka, Y. Takashima, H. Nagahara, Y. Takenaka, K. Yoshikawa, H. Okamura, and R. Kageyama, “Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells”, Proc. Natl. Acad. Sci. USA, 103, 1313-1318 (2006). |
| 誌名: | Proceedings of the National Academy of Sciences (PNAS) |
| 巻: | 103 |
| 号: | 5 |
| 開始ページ: | 1313 |
| 終了ページ: | 1318 |
| 抄録: | Expression of the bHLH gene Hes1 oscillates stably in the presomitic mesoderm (PSM) while transiently in other cells, suggesting that the Hes1 oscillators in the former and the latter could be intrinsically different. Real-time bioluminescence imaging of Hes1 expression showed that the Hes1 oscillation is robust and stable in the PSM while unstable in most individual fibroblasts and dissociated PSM cells. Thus, the Hes1 oscillators in individual PSM cells and fibroblasts are intrinsically similar, and these results, together with mathematical simulation, suggest that the cell-cell communication is essential not only for synchronization but also for stabilization of cellular oscillators. |
| 著作権等: | Copyright © 2006 by the National Academy of Sciences この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
| URI: | http://hdl.handle.net/2433/49175 |
| DOI(出版社版): | 10.1073/pnas.0508658103 |
| PubMed ID: | 16432209 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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