HYDROXYLYSYL GLYCOSIDE CONTENT IN SKIN OF MICE: INFLUENCES OF AGING AND SEX ON HYDROXYLYSYL DISACCHARIDE

Abstract

Hydroxylysyl disaccharide in skin collagen of DDD strain mice was analyzed for the purpose of clarifying influences of aging and sex by column chromatography. There were remarkable differences between hydroxylysyl disaccharide contents in skin collagen in DDD strain mice at 3 weeks of age and those at 5, 8, 12 weeks of age. 1) The contents were maximum at 3 weeks of age in both sexes. They rapidly decreased at 5 weeks of age and hardly changed thereafter. 2) The contents were less in female than in male at 3 weeks of age, whereas they were always more in female than in male at 5, 8, 12 weeks of age. There is an inverse relationship between those biological changes and morphological changes such as changes of collagen fibril size. It is also suggested that those biological changes seem to precede morphological changes in some extent.