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Title: Dissociation of DNA–polycation complexes by polyanions and polyampholytes
Authors: Shew, Chwen-Yang
Yoshikawa, Kenichi
Ito, Tomoko
Yoshihara, Chieko
Koyama, Yoshiyuki
Author's alias: 吉川, 研一
Issue Date: Sep-2007
Publisher: Elsevier
Citation: C.Y. Shew, K. Yoshikawa, T. Ito, C. Yoshihara, and Y. Koyama “Dissociation of DNA-polycation complex by polyanions and polyampholytes“, Chem. Phys. Lett. 446 (2007)
Journal title: Chemical Physics Letters
Volume: 446
Issue: 1-3
Start page: 59
End page: 64
Abstract: Both polyanions and polyampholytes cause the dissociation of DNA–polycation complexes in experiments. To elucidate their mechanisms, Monte Carlo simulations have been conducted on a simple model, with DNA modeled as an infinite charged cylinder and other polyions treated as charged Shish–Kebab rods. Our results show that a highly charged polyanion is required to separate a polycation from a DNA. However, for a diblocked polyampholyte, its net dipole induces a higher probability to bridge a DNA and a polycation. Thus, the loosening mechanisms are found to be markedly different between polyanions and polyampholytes.
Rights: Copyright © 2007 Elsevier B.V. All rights reserved.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1016/j.cplett.2007.08.046
Appears in Collections:Journal Articles

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