Downloads: 36154
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Yamanaka_Cell_131_5.pdf | 4 MB | Adobe PDF | View/Open |
Title: | Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors |
Authors: | Takahashi, Kazutoshi ![]() ![]() Tanabe, Koji Ohnuki, Mari Narita, Megumi Ichisaka, Tomoko Tomoda, Kiichiro Yamanaka, Shinya ![]() ![]() |
Author's alias: | 高橋, 和利 田邊, 剛士 大貫, 茉里 成田, 恵 一阪, 朋子 友田, 紀一郎 山中, 伸弥 |
Issue Date: | 30-Nov-2007 |
Publisher: | Elsevier B.V. |
Citation: | Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007 Nov 30;131(5):861-72. |
Journal title: | Cell |
Volume: | 131 |
Issue: | 5 |
Start page: | 861 |
End page: | 872 |
Abstract: | Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from mouse somatic cells by transduction of four defined transcription factors. Here, we demonstrate the generation of iPS cells from adult human dermal fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc. Human iPS cells were similar to human embryonic stem (ES) cells in morphology, proliferation, surface antigens, gene expression, epigenetic status of pluripotent cell-specific genes, and telomerase activity. Furthermore, these cells could differentiate into cell types of the three germ layers in vitro and in teratomas. These findings demonstrate that iPS cells can be generated from adult human fibroblasts. |
Rights: | Copyright © 2007 Elsevier B.V. All rights reserved. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/49782 |
DOI(Published Version): | 10.1016/j.cell.2007.11.019 |
Appears in Collections: | Journal Articles |

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.