STUDY ON TUBERCULOSTATIC ACTIVITIES OF BODY FLUIDS OF RABBITS GIVEN TRITON WR1339 WITH SPECIAL REFERENCE TO THE ROLE OF LIPEMIA

Abstract

With the chamber method, it was demonstrated that body fluid completely separated from cells of rabbits treated with either large dose (500mg per Kg) or small dose (100mg per Kg) of Triton WR1339 showed increased static activity on the growth of tubercle bacilli in vivo. Cloudiness of serum (lipemia) had no relation to this activity, and lipemia induced by feeding rabbits a high cholesterol diet did not affect the resistance of body fluid to tuberculosis. Hikasa's neutral fat emulsion did not increase the ability of body fluid to inhibit the growth of tubercle bacilli in vivo.