III. Further Studies on the Decomposition of Tyrosine-Derivatives by Mycobacterium Tuberculosis. (Studies of Metabolism in Tuberculous Lesions)

Abstract

By the action of mycobacterium tuberculosis avium (Takeo), (1) The author recognized and detected the formation of N-acetyltyramine on the decomposition of tyramine in Lactose-Media by the same methods as in Glucose-Media, and at the same time, tyrosol was also formed. (2) In Pyruvic-Media tyramine was decomposed and small amounts of N-acetyltyramine can be obtained in a crystalline form. (3) By use of N-acetyltyramine which was formed from tyramine by mycobacterium tuberculosis avium (Takeo), the following experiments were performed. a) In Glucose-Media, although N-acetyltyramine was decomposed by mycobacterium, the formations of tyramine and tyrosol were observed obscurely and the formation of p-hydroxyphenyl-acetic acid was detectable. b) In Glycerin Media, the N-acetyltyramine was decomposed in the same way. In this case, the tyramine formation was doubtful but tyrosol was obtained in small quantities and p-hydroxyphenyl-acetic acid formation was appeared.