<原著>喫煙の気管支肺胞洗浄液 (BALF) 細胞, 末梢血細胞に及ぼす影響に関する検討

Abstract

It has been reported that smoking causes various pulmonary disorders including lung cancer, pulmonary emphysema and some interstitial lung diseases. To evaluate the influence of smoking on the human lung, we compared BALF cells findings of non-smokers, smokers and ex-smokers. The results are as follows : 1. A significant decrease of BALF recovery and an increase in the number of BALF cell in smokers were found compared to those in non-smokers. 2. Among the BALF cell populations, a significant increase of BALF macrophages were found in smokers compared to non-smokers. No such a difference could be found as to lymphocytes. 3. As to the subsets of BALF macrophages, a significant icrease of OKM1^+, OKM5^+ and OKT6^+ cells in smokers were found compared to those in non-smokers. 4. As to the subset of BALF lymphocytes, a significant increase of OKT8^+ cells and decrease of OKT4^+ cells in smokers resulted in a significant decrease of OKT4^+/OKT8^+ ratio. The above results contribute to an understanding of the mechanism of lung injuries attributable to smoking and also the understanding of the pathogenesis of tobacco-related lung diseases.