<原著>肺結核症例における気管支肺胞洗浄細胞成分, 特にモノクローナル抗体を用いた細胞サブセットに関する検討

Abstract

Cellular components of BALF obtained from affected and normal lungs with pulmonary tuberculosis showing a unilateral infiltrative caseous lesion were compared with those of patients with sarcoidosis and normal subjects. 1. In the BALF from affected lungs with the lesion of pulmonary tuberculosis, findings suggesting proliferation and accumulation of lymphocytes were observed, but no particular tendency was found in subsets. Macrophages also increased in number, particularly OKM1^+ macrophages. 2. The number of E37℃ lymphocytes, Tac^+ lymphocytes, and OKIa1^+ lymphocytes and the OKT4^+/OKT8^+ ratio in the BALF from the bilateral lung, which are considered as associated with dissemination of ativated cells via blood circulation, showed a tendency to increase. In the peripheral blood also, increases in OKIa1^+ monocytes, E37℃ lymphocytes, and Tac^+ lymphocytes were observed. 4. Similar findings were obtained in the patients with sarcoidosis in the active stage. These results suggest that the formation epithelioid of granuloma in pulmonary tuberculosis occurs by a mechanism similar to that in sarcoidosis.