<原著>第 1 篇選択的経リンパ行-制癌剤投与法の実験的研究(選択的経リンパ行性制癌剤投与法に関する研究)

Abstract

As a means of determining the reliability of intralymphatic anticancer therapy, we designed an experimental study performed on XV2 tumor in the rabbit. VX2 tumor suspension was injected into the epigastric lymphatics to develop microscopic lymph node metastases. After a 5-day interval, S/O emulsion containing 1mg/kg bleomycin was injected into the same lymphatics. The anti-tumor responses were evaluated by histological examination of the drainage lymph nodes at 10days after tumor transplantation. The VX2 tumor cells growing in the marginal sinus were all degenerated and numerous micronecroses throughout the lymph node and tumor were observed. With this experimental method it was demonstrated that our intralymphatic administration of anticancer agents with sustained pharmacological action had sufficient effects on the metastatic lymph nodes.