アレルギー性肉芽腫症・血管炎(Churg-Strauss 症候群)の 1 例

Abstract

A 24-year-old male with asthma, who complained of fever, dyspnea, cough, bloody sputum and general fatigue, was histopathologically diagnosed as allergic granulomatosis and angitis (Churg-Strauss syndrome) by both open lung and skin biopsy. The symptom subsided and his chest roentogenogram improved by glucocorticoid therapy and has been doing well with a maintenance dose (15mg) of predonisolone for six months. Allergic granulomatosis and angitis was first reported by Churg and Strauss in 1951, which was characterized histologically by necrotizing vasculitis of small arteries and veins with extravascular granulomas and with infiltration of eosinophils to the vessels and perivascular tissues, and clinically by bronchial asthma, fever and hypereosinophilia. The disease is said to involve many organs, most frequently the lung, peripheral nerves and skin.