<原著>薬剤の胸膜透過性の検討

Abstract

In the treatment of pyothorax and pleurisy, effective antibiotics against the etiological bacilli have been instilled into the thoracic cavity or antibiotic solutions have been used to irrigate the cavity. For carcinomatous pleurisy, anticancer drugs have been administered systemically or locally, and for prophylaxis against the spread of cancer cells anticancer drugs have been placed in the pleural cavity during operation. Besides these local therapies, systemic medication has, of course, also been given. However, the transport of these agents to and from through the pleura is not yet completely understood. Therefore, we studied the movement of antibiotics and anticancer drugs through the pleura into the blood following intrapleural instillation and into the pleural fluid after systemic therapy. The results were evaluated in patients with unthickened and those with thickened pleura. In patients with unthickened pleura, permeability was rapid, but in those with thickened pleura permeability showed a negative correlation with pleural thickening. Thus, after intrapleural instillation, drugs remain at high levels for a long time within the pleural cavity and are thought to be more effective in patients with pleural thickening.