<原著>結核菌の発育に不適当な条件と化学療法 : 第 1 篇結核菌発育阻止効果について

Abstract

Chemotherapeutic effects of RFP alone, two drug regimen of RFP・EB and three drug regimen of RFP・EB・INH to Mycobacterium tuberculosis H_<37>Rv were evaluated in vitro by changing the incubating temperature at 37℃, 25℃ and 4℃. Comparing the results obtained at 25℃ and 4℃ with those at 37℃, the chemotherapeutic effects were remarkably lowered in the incubating temperature, 25℃ and 4℃ even in the three drug regimen and the development of drug resistance RFP was not observed in such an inadequate condition for the growth of tubercle bacilli. According to these results, it seems slmost impossible to intensify the antituberculosis chemotherapeutic effect under the thermal condition inadequate for the growth of tubercle bacilli in vitro.