<Original Report>DISTRIBUTION AND METABOLISM OF BENZO (a) PYRENE IN FETAL MOUSE

Abstract

The distribution of benzo(a)pyrene given i. v. into a pregnant mouse was observed by macroautoradiography. Small amount of BP was transferred into fetus, indicating the highest concentration into the intestinal tract and next in the liver and kidneys in the fetus near term. However the lung was labeled very low in spite of the most susceptable organ in transplacental carcinogenesis. Radiometric analysis revealed that intact BP and its metabolites were detected in the fetal tissues during various developmental stages. Hydroxy compounds were metabolized into conjugated materials and excreted through the intestinal tract of the fetus near term.