<原著>実験的甲状腺炎における自己反応細胞 : I. Plaque Forming Cell の検索

Abstract

It was demonstrated that the subcutaneous (or footpads) administration of thyroid extracts with various kinds of adjuvants caused the production of thyroid-specific antibodies in guinea pigs and the development of extensive lymphocytic infiltration in the thyroid gland. The skin reaction against thyroglobulin of the treated animals was strongly positive 2 weeks after the treatment, while the titre of humoral antibodies remained low. The titres in anti-thyroglobulin antibodies shown by passive haemagglutination became higher in the more advanced stages (4 weeks). In these cases, the enumeration of plaque forming cells producing anti-thyroglobulin antibodies in the spleen, lymph nodes and thyroid glands were carried out, and no plaque forming cells were shown in these organs.