<原著>〔第 1 篇〕実験的研究(肺癌手術に対する補助化学療法に関する実験的ならびに臨床的研究)

Abstract

Experimental and clinical studies were made on the prevention of vascular dissemination of cancer by the "shower" of cancer cells during surgical operation for lung cancer. In an experimental study using Ehrlich ascites tumor cells and DDD-female mice, the effect of Mitomycin-C was examined. The results are summarized as follows. 1) The drug showed more carcinostatic effect when it was injected immediately after intravasation of cancer cells, than when it was injected 24 hours or more after the intravasation. 2) This carcinostatic agent showed a more marked carcinostatic effect in vivo than in vitro. 3) With low concentrations fo carcinostatic agent, the socalled "adverse effect" was seen in some cases. 4) Carcinostatic effects depend on the concentration of drugs and not on the duration of reaction. On the basis of these results, we decided on a schedule of adjuvant chemotherapy for lung cancer surgery, including intravenous injection of large doses of drugs during operation. We treated 48 cases on this schedule; the results of the clinical study are summarized as follows 1) In selecting the drugs, one must consider the sensitivity of individual cells to each drug. The succinic dehydrogenase inhibition method (Kondo) was investigated, and it was found that the sensitivity of cancer cells tended to depend somewhat on the histologic type. Sensitivity tests for each cancer cell will be most important in the future. 2) No severe side effect was seen in the patients in this series. 3) The prognosis for these patients proved to be better than for patients in the control group in terms of one-year survival rates.