Arranging Functional Quarternary Structures of DNA Binding Peptides (BIOORGANIC CHEMISTRY-Bioactive Chemistry)

Abstract

Our research seeks to use a combination of synthetic, organic biochemical and molecular biological approaches to study the principle of molecular recognition associated with biological macromolecules. We have focused mainly on the action of transcription factors, especially that of the basic leucine zipper proteins. The model systems described herein have been used to address the issues of protein-protein and protein-DNA recognitions in far greater detail than is possible with the native protein systems.