ダウンロード数: 1262
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
v5-p52.pdf | 22.84 kB | Adobe PDF | 見る/開く |
タイトル: | NLS (Nuclear Localization Signal) Prediction (MOLECULAR BIOLOGY AND INFORMATION?Biological Information Science) |
キーワード: | Nuclear transport Protein sorting Database Bioinformatics |
発行日: | Mar-1999 |
出版者: | Institute for Chemical Research, Kyoto University |
誌名: | ICR Annual Report |
巻: | 5 |
開始ページ: | 52 |
終了ページ: | 53 |
抄録: | The nucleus of eukaryotic cells contains many nuclear proteins that function for delivery of molecular information between cytosol and nucleus, and for control of gene expression. After the synthesis on the ribosomes in the cytoplasm, these proteins enter the nucleus through pore complexes in the nuclear envelope. Nuclear proteins are transported into the nucleus, if they contain nuclear localization signals (NLSs). In this work we developed a method that predicts a location of NLS on a query protein sequence by computational analysis. We employed Hidden Markov Model (HMM) in our method to find NLSs in the amino acid sequences. The prediction performance was assessed by leave-one-out cross-validation. |
URI: | http://hdl.handle.net/2433/65182 |
出現コレクション: | Vol.5 (1998) |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。