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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| v5-p38.pdf | 43.22 kB | Adobe PDF | 見る/開く |
| タイトル: | Conformational Effect (Induced-Fit) on Catalytic Activity of a-Chymotrypsin (BIOORGANIC CHEMISTRY-Bioorganic Reaction Theory) |
| 著者: | Kawai, Yasushi Matsuo, Takashi Ohno, Atsuyoshi |
| キーワード: | Induced-Fit Theory a-Chymotrypsin Medium Viscosity Catalytic Activity |
| 発行日: | Mar-1999 |
| 出版者: | Institute for Chemical Research, Kyoto University |
| 誌名: | ICR Annual Report |
| 巻: | 5 |
| 開始ページ: | 38 |
| 終了ページ: | 39 |
| 抄録: | The kinetics for the hydrolyses of p-nitrophenyl esters of acetic acid and certain amino acid derivatives mediated by a-chymotrypsin have been studied. The kinetics are a function of the medium viscosity, which indicate that the enzyme must change its conformation during the reaction. Detailed analysis of the dependence of kinetic rate constants on the medium viscosity has revealed that the induced-fit conformational adjustment of enzyme plays a crucial role in its catalytic activity. |
| URI: | http://hdl.handle.net/2433/65189 |
| 出現コレクション: | Vol.5 (1998) |
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