Nucleocytoplasmic Transport of Preintegration Complex and Viral mRNA in Retrovirus-InfectedCells (BIOORGANIC CHEMISTRY-Molecular Clinical Chemistry)

Abstract

Active transport of proteins and mRNAs between the nucleus and cytoplasm is a major process in eukaryotic cells. Recently, factors that recognize transport substrates and mediate nuclear import or export have been characterized, revealing interactions that target substrates to the nuclear pore complexes, through which translocation occurs. In the first half of the report, nuclear import of the human immunodeficiency virus 1 (HIV-1) preintegration complex (PIC) is discussed. The second half describes recent information on the mechanistic details of nuclear export of viral mRNA so-called Revdependent trans-activation of viral genes.