肝硬変合併腎細胞癌術後4年目に発見された孤立性対側副腎転移の1例

Abstract

52歳男。4年前に肝硬変(ウイルス性C型肝炎)と腎機能障害の経過観察中のCT, MRI検査で左腎上極に径4cm大腫瘤を指摘された。脾機能亢進症状で血小板減少を認めたため部分的脾動脈塞栓術(PSE)施行後5週目に経腰的左腎摘出術を施行し左副腎は温存した。腫瘍部は5×5×4cm大で病理所見ではrenal cell carcinoma, granular cell carcinoma, G2pT1b, StageIであった。2～3ヵ月毎の経過観察で再発・転移兆候は認めなかったが, 手術後約3年半のMRIで右副腎に径2.5cm大の腫瘤を認め増大傾向にあるため精査加療目的入院となった。T1WIで中間信号, T2WIでやや高信号域, CTより右副腎は2.5×3cm 大に腫大し, 副腎皮質シンチで両副腎に取り込みを認め, 6ヵ月後に後腹膜鏡下右副腎摘除術を施行した。腫瘍は4×4.5×2cm大の割面は黄褐色でRCC clear cellの転移病巣で, 病理所見よりrenal cell carcinomaと判明した。術後9日目に退院し, 免疫療法は施行せず, 術後7ヵ月現在再発・転移の兆候は認めていない。

We report a case of adrenal metastasis from renal cell carcinoma. A 52-year-old man was referred to our hospital for a left renal mass. A computed tomography revealed a left renal tumor. Liver cirrhosis and splenomegaly were observed. Blood tests revealed pancytopenia; platelet count was 2.5 x 10(4)/mm3. The patient was treated by partial splenic embolization (PSE) in an attempt to ensure a safe nephrectomy. After the embolization, his platelet count increased to 6.1 x 10(4)/mm3, and left nephrectomy was performed successfully. Histopathological finding was renal cell carcinoma (RCC). We concluded that PSE before surgery was useful for the patients with thrombocytopenia due to hypersplenism. Four years after surgery, computed tomography revealed the presence of a mass on the right adrenal gland. He was suspected of having a non-functioning adrenal tumor. Metastasis of the RCC was suspected and right adrenalectomy was performed by a laparoscopic procedure. Histologically, the mass was identified as a RCC metastasis. It is clinically rare for an RCC metastasis to the contralateral adrenal gland to occur.