諸種藥物の併用に依る催眠藥作用並に鎖痛藥作用の增强(第3報)

Abstract

Recently Slaughter et al. reported that eserine and prostigmine potentiated the analgesic action of morphine, and Frommel et al that prostigmine as well as analogous anticholinesterase agents potentiated the hypnotic action of barbiturates. Both of them made the same suggestion that these actions were attributable to the cholinergic effects of the drugs. We carried out the similar investigation by attaching importance to the anticholinesterase action of drugs. At the same time two synthesized drugs〔P-aminobenzoylcholine chloride (Me3-Procaine), N-(dimethylaminoethyl)-Phenothiazine methochloride (Me3-Anergen)〕 which have Me3-N group and were proved to have anticholinesterase action, and methylenblue which were used in neuralgia since Ehrlich advocated the effect, because of its strong affinity to the sensitive nerve and were reported to have strong anticholinesterase action by Rentz, and some other few synthetic dyes as methylgreen, methylviolet, were employed to investigate whether they potentiate the action of morphine and evipan. The result obtained were compared with those results in the previous report.