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タイトル: | 症状日誌を用いた前立腺肥大症に対するTamsulosin投与1週間の即効性評価の試み |
その他のタイトル: | One-Week Effects of Tamsulosin on Benign Prostatic Hyperplasia Assessed with a Daily Symptom Score |
著者: | 冨田, 雅之 頴川, 普 池本, 庸 中條, 洋 波多野, 孝史 吉良, 慎一郎 水尾, 敏彦 各務, 裕 |
著者名の別形: | Tomita, Masayuki Egawa, Shin Ikemoto, Isao Nakajo, Hiroshi Hatano, Takashi Kira, Shinichiro Mizuo, Toshihiko Kagami, Yutaka |
キーワード: | Benign prostatic hyperplasia Tamsulosin Early effects Eviprostat Daily symptom score |
発行日: | Apr-2009 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 55 |
号: | 4 |
開始ページ: | 193 |
終了ページ: | 197 |
抄録: | The early effects of Tamsulosin within one week of administration on lower urinary tract symptoms in patients with benign prostatic hyperplasia (BPH) were investigated. Patients with newly diagnosed BPH were randomized into a Tamsulosin group and a Eviprostat group. Changes in subjective symptoms daily for 7 days after the start of administration and in the 4th week (8 times in total) were evaluated using seven symptoms in the International Prostate Symptom Score (IPSS) and the quality of life (QOL) index entered in a self-scoring diary kept by the patients daily. In the Tamsulosin group, the IPSS total score showed significant improvements. Significant improvements were observed in the incomplete emptying and frequency scores from the day after the start of administration, in the intermittency and straining scores from day 2, in the urgency and weak stream scores from day 3 and in the nocturia score from day 5. The QOL index significantly improved on day 7. In comparison with Eviprostat, Tamsulosin showed a stronger improvement tendency in the total IPSS, voiding symptoms score and incomplete emptying score and the difference was significant. The difference between the two groups was especially marked for the intermittency and weak stream scores and Tamsulosin showed significantly better early effects. Tamsulosin also showed significantly better early effects than Eviprostat in the QOL index. In conclusion, it was clear that Tamsulosin caused significant improvement in lower urinary tract symptoms associated with BPHas a whole from a very early stage within one week after administration. |
著作権等: | 許諾条件により本文は2010-05-01に公開 |
URI: | http://hdl.handle.net/2433/74776 |
PubMed ID: | 19462823 |
出現コレクション: | Vol.55 No.4 |
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