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dc.contributor.author | Fujii, Takao | en |
dc.contributor.author | Okada, Masato | en |
dc.contributor.author | Fujita, Yoshimasa | en |
dc.contributor.author | Sato, Takeshi | en |
dc.contributor.author | Tanaka, Masao | en |
dc.contributor.author | Usui, Takashi | en |
dc.contributor.author | Umehara, Hisanori | en |
dc.contributor.author | Mimori, Tsuneyo | en |
dc.contributor.alternative | 藤井, 隆夫 | ja |
dc.date.accessioned | 2009-09-18T06:46:02Z | - |
dc.date.available | 2009-09-18T06:46:02Z | - |
dc.date.issued | 2009-09 | - |
dc.identifier.issn | 0896-8411 | - |
dc.identifier.uri | http://hdl.handle.net/2433/85221 | - |
dc.description.abstract | We studied the efficacy of T cell vaccination with CD4+αβTh1 clones in lupus-prone MRL/Mp-Faslpr/lpr (MRL/lpr) mice. CD4+αβ Th1 clones, dna51 (Vβ8.3) and rnp2 (Vβ14), which stimulated anti-dsDNA or U1 ribonucleoprotein (U1RNP) antibody (Ab) production respectively, were isolated from splenocytes of MRL/lpr mice. Antinuclear Ab kinetics, renal function, renal histology, survival rate, and lymphocyte subpopulations in the spleen were monitored after intravenous adoptive transfer of IL-2-stimulated (s-) or irradiated (i-) clones to 3 week-old female MRL/lpr mice. Anti-idiotypic humoral and T cell responses against the transferred autoreactive Th1 clones were determined in parallel. Compared with PBS-treated MRL/lpr mice, anti-dsDNA Ab titers, and the activity index for lupus nephritis were all decreased in MRL/lpr mice vaccinated with i-dna51 cells, whereas survival rate was not improved. The numbers of CD4+Vβ8.3 T cells in the spleen were also significantly decreased in these mice. Anti-idiotypic Abs recognizing a 12 amino acid sequence of clone dna51 T cell receptor Vβ8.3-complementarity-determining region (CDR) 3 were detected in the MRL/lpr mice that received i-dna51 or s-dna51 cells. These Abs suppressed dna51 cell proliferation, as well as cytotoxicity of CD8+T cells against dna51. The present study suggests that vaccination with CD4+αβTh1 clone, dna51, elicits anti-idiotypic T cell and humoral responses against dna51 in MRL/lpr mice, although the immunoregulatory effects on lupus may be limited. | en |
dc.language.iso | eng | - |
dc.publisher | Elsevier | en |
dc.rights | c 2009 Elsevier Ltd. All rights reserved. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.title | Vaccination with autoreactive CD4+Th1 clones in lupus-prone MRL/Mp-Faslpr/lpr mice | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Journal of Autoimmunity | en |
dc.identifier.volume | 33 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 125 | - |
dc.identifier.epage | 134 | - |
dc.relation.doi | 10.1016/j.jaut.2009.06.001 | - |
dc.textversion | author | - |
dc.identifier.pmid | 19596182 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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