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dc.contributor.authorYokoo, Noritakaja
dc.contributor.authorBaba, Shiroja
dc.contributor.authorKaichi, Shinjija
dc.contributor.authorNiwa, Akiraja
dc.contributor.authorMima, Takahiroja
dc.contributor.authorDoi, Hirakuja
dc.contributor.authorYamanaka, Shinyaja
dc.contributor.authorNakahata, Tatsutoshija
dc.contributor.authorHeike, Toshioja
dc.contributor.alternative横尾, 憲孝ja
dc.contributor.alternative平家, 俊男ja
dc.contributor.alternative山中, 伸弥ja
dc.date.accessioned2009-09-18T07:24:31Z-
dc.date.available2009-09-18T07:24:31Z-
dc.date.issued2009-09ja
dc.identifier.issn0006-291Xja
dc.identifier.urihttp://hdl.handle.net/2433/85222-
dc.description.abstractDeveloping effective drug therapies for arrhythmic diseases is hampered by the fact that the same drug can work well in some individuals but not in others. Human induced pluripotent stem (iPS) cells have been vetted as useful tools for drug screening. However, cardioactive drugs have not been shown to have the same effects on iPS cell-derived human cardiomyocytes as on embryonic stem (ES) cell-derived cardiomyocytes or human cardiomyocytes in a clinical setting. Here we show that current cardioactive drugs affect the beating frequency and contractility of iPS cell-derived cardiomyocytes in much the same way as they do ES cell-derived cardiomyocytes, and the results were compatible with empirical results in the clinic. Thus, human iPS cells could become an attractive tool to investigate the effects of cardioactive drugs at the individual level and to screen for individually tailored drugs against cardiac arrhythmic diseases.ja
dc.language.isoengja
dc.publisherElsevierja
dc.rightsc 2009 Elsevier Inc. All rights reserved.ja
dc.rightsこの論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.ja
dc.subjectArrhythmiaja
dc.subjectCardiomyocytesja
dc.subjectDrug loading testja
dc.subjectHuman embryonic stem cellja
dc.subjectHuman induced pluripotent stem cellja
dc.titleThe effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cellsja
dc.type.niitypeJournal Articleja
dc.identifier.jtitleBiochemical and Biophysical Research Communicationsja
dc.identifier.volume387ja
dc.identifier.issue3ja
dc.identifier.spage482ja
dc.identifier.epage488ja
dc.relation.doi10.1016/j.bbrc.2009.07.052ja
dc.textversionauthorja
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