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Title: Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma
Authors: Narita, Masato
Hatano, Etsuro
Arizono, Shigeki  kyouindb  KAKEN_id  orcid (unconfirmed)
Miyagawa-Hayashino, Aya
Isoda, Hiroyoshi  kyouindb  KAKEN_id
Kitamura, Koji
Yasuchika, Kentaro  kyouindb  KAKEN_id
Nitta, Takashi
Uemoto, Shinji  kyouindb  KAKEN_id
Author's alias: 波多野, 悦朗
Keywords: Gd-EOB-DTPA
Green hepatoma
Issue Date: Jul-2009
Publisher: Springer Verlag
Journal title: Journal of Gastroenterology
Volume: 44
Issue: 7
Start page: 793
End page: 798
Abstract: Background: Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is an MRI contrast agent with perfusion and hepatoselective properties. The purpose of the study was to examine uptake of Gd-EOB-DTPA in the hepatobiliary phase in hepatocellular carcinoma (HCC). Methods: A retrospective analysis of 22 patients with HCC who underwent preoperative Gd-EOB-DTPA-enhanced MRI was performed. Enhancement ratios (ERs) and expression levels of the organic anion transporter (OATP) 1B3 protein were examined. Results: Gd-EOB-DTPA accumulated in the hepatobiliary phase in 6 of the 22 cases. All 6 Gd-EOB-DTPA-positive cases were moderately differentiated HCC, but 11 other moderately differentiated HCCs did not show Gd-EOB-DTPA uptake. Histopathologically, 4 Gd-EOB-DTPA-positive HCCs and 5 Gd-EOB-DTPA-negative HCCs produced bile. HCCs with Gd-EOB-DTPA uptake overexpressed OATP1B3 compared with HCCs without Gd-EOB-DTPA uptake, and OATP1B3 levels were significantly correlated with ERs (r = 0.91, P < 0.0001). Conclusions: Uptake of Gd-EOB-DTPA in HCC is determined by expression of OATP1B3 rather than by tumor differentiation or bile production.
Rights: c Springer 2009.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1007/s00535-009-0056-4
PubMed ID: 19404564
Appears in Collections:Journal Articles

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