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タイトル: | Microbial production of conjugated fatty acids |
著者: | Kishino, Shigenobu https://orcid.org/0000-0002-4587-2422 (unconfirmed) Ogawa, Jun https://orcid.org/0000-0003-2741-621X (unconfirmed) Yokozeki, Kenzo Shimizu, Sakayu |
著者名の別形: | 岸野, 重信 |
発行日: | Sep-2009 |
出版者: | Elsevier Advanced Technology |
誌名: | Lipid Technology |
巻: | 21 |
号: | 8-9 |
開始ページ: | 177 |
終了ページ: | 181 |
抄録: | Conjugated fatty acids have attracted much attention as a novel type of biologically beneficial functional lipid. Some isomers of conjugated linoleic acid (CLA) reduce carcinogenesis, atherosclerosis and body fat. Considering the use of CLA for medicinal and nutraceutical purposes, a safe isomer-selective process of production is required. The introduction of biological reactions for CLA production could be an answer. We screened microbial reactions useful for CLA production and found several unique reactions in microorganisms. Lactic acid bacteria produced CLA from linoleic acid. The CLA, which was obtained as the free fatty acid form, comprised a mixture of cis-9, trans-11- octadecadienoic acid (18:2) and trans-9, trans-11-18:2. Furthermore, lactic acid bacteria transformed ricinoleic acid [12-hydroxy-cis-9- octadecenoic acid (18:1)] to CLA (a mixture of cis-9, trans-11-18:2 and trans-9, trans-11-18:2). Castor oil, rich in the triacylglycerol form of ricinoleic acid, was also found to act as a substrate for CLA production by lactic acid bacteria with the aid of lipase-catalyzed triacylglycerol hydrolysis. Filamentous fungi transformed trans-vaccenic acid (trans-11-18:1) to cis-9, trans-11-18:2 by Δ9 desaturation.This CLA was obtained as a triacylglycerol.In addition, lactic acid bacteria produced conjugated trienoic fatty acids from α- and γ-linolenic acid. The trienoic fatty acids produced from α-linolenic acid were cis-9, trans-11, cis-15-octadecatrienoic acid (18:3) and trans-9, trans-11, cis-15-18:3. Those produced from γ-clinolenic acid were cis-6, cis-9, trans-11-18:3 and cis-6, trans-9, trans-11-18:3. |
著作権等: | c 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/91449 |
DOI(出版社版): | 10.1002/lite.200900044 |
出現コレクション: | 学術雑誌掲載論文等 |
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