2. Study on Melting Process of DNA Double Helix by 5-pass Brillouin Spectroscopy

Abstract

It has been of great interest to clarify the dynamical mechanism of the melting process in the DMA double helix, because the melting phenomena have been found to relate closely with the basic molecular biological process, such as the replication and the transcription of genetic information. The melting phenomena can be caused not only by the interaction with enzymes but also by increasing the temperature. Numerous investigations on the melting phenomena of the DNA double helix in dilute solution have been carried out by means of absorption spectroscopy, circular dichroisrn and other methods with increasing temperature. But there have been only a few studies on the dynamical mechanism of the melting process in the condensed state.