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j.bbrc.2009.12.154.pdf | 2.11 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Shintani, Tomoya | en |
dc.contributor.author | Yamazaki, Fumiyoshi | en |
dc.contributor.author | Katoh, Toshihiko | en |
dc.contributor.author | Umekawa, Midori | en |
dc.contributor.author | Matahira, Yoshiharu | en |
dc.contributor.author | Hori, Seiji | en |
dc.contributor.author | Kakizuka, Akira | en |
dc.contributor.author | Totani, Kazuhide | en |
dc.contributor.author | Yamamoto, Kenji | en |
dc.contributor.author | Ashida, Hisashi | en |
dc.contributor.alternative | 芦田, 久 | ja |
dc.date.accessioned | 2010-02-04T07:17:25Z | - |
dc.date.available | 2010-02-04T07:17:25Z | - |
dc.date.issued | 2010-01-22 | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | http://hdl.handle.net/2433/93625 | - |
dc.description.abstract | Autophagy is a cellular process that nonspecifically degrades cytosolic components and is involved in many cellular responses. We found that amino sugars with a free amino group such as glucosamine, galactosamine and mannosamine induced autophagy via an mTOR-independent pathway. Glucosamine-induced autophagy at concentrations of at least 500 microM to over 40 mM. In the presence of 40 mM glucosamine, autophagy induction was initiated at 6h and reached a plateau at 36 h. Glucosamine-induced autophagy could remove accumulated ubiquitin-conjugated proteins as well as 79-glutamine repeats. Therefore, orally administered glucosamine could contribute to the prevention of neurodegenerative diseases and promotion of antiaging effects. | en |
dc.language.iso | eng | - |
dc.publisher | Elsevier | en |
dc.rights | © 2010 Elsevier Inc. All rights reserved. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | Autophagy | en |
dc.subject | Chitin | en |
dc.subject | Chitosan | en |
dc.subject | Glucosamine | en |
dc.subject | Hexosamine | en |
dc.subject | Polyglutamine disease | en |
dc.title | Glucosamine induces autophagy via an mTOR-independent pathway. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Biochemical and biophysical research communications | en |
dc.identifier.volume | 391 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 1775 | - |
dc.identifier.epage | 1779 | - |
dc.relation.doi | 10.1016/j.bbrc.2009.12.154 | - |
dc.textversion | author | - |
dc.identifier.pmid | 20045674 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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