ダウンロード数: 324
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
v06p0305.pdf | 477.12 kB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Kuwahara, Akiko | en |
dc.contributor.author | Yamamori, Motohiro | en |
dc.contributor.author | Nishiguchi, Kohshi | en |
dc.contributor.author | Okuno, Tatsuya | en |
dc.contributor.author | Chayahara, Naoko | en |
dc.contributor.author | Miki, Ikuya | en |
dc.contributor.author | Tamura, Takao | en |
dc.contributor.author | Inokuma, Tsubasa | en |
dc.contributor.author | Takemoto, Yoshiji | en |
dc.contributor.author | Nakamura, Tsutomu | en |
dc.contributor.author | Kataoka, Kazusaburo | en |
dc.contributor.author | Sakaeda, Toshiyuki | en |
dc.contributor.alternative | 栄田, 敏之 | ja |
dc.date.accessioned | 2010-02-17T06:42:14Z | - |
dc.date.available | 2010-02-17T06:42:14Z | - |
dc.date.issued | 2009-06 | - |
dc.identifier.issn | 14491907 | - |
dc.identifier.uri | http://hdl.handle.net/2433/97922 | - |
dc.description.abstract | Objective: The effects of replacing cisplatin (CDDP) with cis-diammineglycolatoplatinum (nedaplatin, NDP), a second-generation platinum complex, on the pharmacokinetics of 5-fluorouracil (5-FU) were investigated in Japanese patients with esophageal squamous cell carcinoma, who were treated with a definitive 5-FU/CDDP-based chemoradiotherapy. Methods: Fifty-six patients were enrolled, 49 treated with CDDP and 7 treated with NDP. A course consisted of continuous infusion of 5-FU at 400 mg/m<sup>2</sup>/day for days 1-5 and 8-12, infusion of CDDP or NDP at 40 mg/m<sup>2</sup>/day on days 1 and 8, and radiation at 2 Gy/day on days 1 to 5, 8 to 12, and 15 to 19, with a second course repeated after a 2-week interval. Plasma concentrations of 5-FU were determined by high performance liquid chromatography at 5 PM on days 3, 10, 38 and45, and at 5 AM on days 4, 11, 39 and 46. Results and conclusions: The circadian rhythm in plasma concentrations of 5-FU observed in the case of CDDP was altered when NDP was used instead. The clinical response can be predicted by monitoring plasma concentrations of 5-FU in the CDDP group, but not in the NDP group. | en |
dc.language.iso | eng | - |
dc.publisher | Ivyspring International Publisher | en |
dc.rights | ©Ivyspring International Publisher | en |
dc.subject | 5-fluorouracil | en |
dc.subject | Chemoradiotherapy | en |
dc.subject | Esophageal squamous cell carcinoma | en |
dc.subject | Nedaplatin | en |
dc.subject | Plasma concentration | en |
dc.title | Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | International Journal of Medical Sciences | en |
dc.identifier.volume | 6 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 305 | - |
dc.identifier.epage | 311 | - |
dc.relation.doi | 10.7150/ijms.6.305 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 19834547 | - |
dc.relation.url | http://www.medsci.org/v06p0305.htm | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。