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ファイル | 記述 | サイズ | フォーマット | |
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19466315.2014.1003090.pdf | 730.47 kB | Adobe PDF | 見る/開く |
タイトル: | Group-Sequential Strategies in Clinical Trials with Multiple Co-Primary Outcomes. |
著者: | Hamasaki, Toshimitsu Asakura, Koko Evans, Scott R Sugimoto, Tomoyuki Sozu, Takashi |
著者名の別形: | 寒水, 孝司 |
キーワード: | Adaptive Type I error allocation Average sample number Equally or unequally spaced increments of information Hierarchical testing procedure Maximum sample size |
発行日: | 18-Mar-2015 |
出版者: | Taylor & Francis Group |
誌名: | Statistics in biopharmaceutical research |
巻: | 7 |
号: | 1 |
開始ページ: | 36 |
終了ページ: | 54 |
抄録: | We discuss the decision-making frameworks for clinical trials with multiple co-primary endpoints in a group-sequential setting. The decision-making frameworks can account for flexibilities such as a varying number of analyses, equally or unequally spaced increments of information and fixed or adaptive Type I error allocation among endpoints. The frameworks can provide efficiency, i.e., potentially fewer trial participants, than the fixed sample size designs. We investigate the operating characteristics of the decision-making frameworks and provide guidance on constructing efficient group-sequential strategies in clinical trials with multiple co-primary endpoints. |
著作権等: | This is an Accepted Manuscript of an article published by Taylor & Francis Group in Statistics in Biopharmaceutical Research on 18/03/2015, available online: http://www.tandfonline.com/10.1080/19466315.2014.1003090. 許諾条件により本文ファイルは2016-03-18に公開. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/198576 |
DOI(出版社版): | 10.1080/19466315.2014.1003090 |
PubMed ID: | 25844122 |
出現コレクション: | 学術雑誌掲載論文等 |
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