尿膠質の研究 第III篇:各種薬剤の尿膠質に及ぼす影響

Abstract

The increasing effects of various amino acids an d medical drugs upon urinary protective colloids has been investigated by three differing procedures : 1) addition of various substances in vitro, 2) administration of various substances to the patients with urolithiasis, 3) salts prezipitated experiment. 1) In this experim ent, both Ogawa's method and Yamazoe's method were utilized as a test for protective activity of urinary colloids. Triptophan, cystine and 1-methionin increased the effect of urinary protective colloids both in Ogawa's method and Yamazoe's method in vitro. On the other hand, arginine hydrochloride, isoleutine, lysin and glutamic acid increased the protective colloidal effect only in Yamazoe's method in vitro. Polytamin, mastigen B12, rutin, neo-strong Minophagen C and its co n stituent components (glycyrrhizine, glycyrrhezic acid and glucose cysteine) incresed the protective colloidal effect both in Yamazoe's method and Ogawa's method in vitro. On the other hand, methio-mastigen B12 revealed the effect only in Ogawa's method, and chondroitin sulfate revealed the effect only in Yamazoe's method. 2) As a clinical experiment, neo-s t r ong Minophagen C, hyaluronidase and chondroitin sulfate were given to the patients with urolithiasis. It was found that neo-strong Minophagen C and chondroitin sulfate increased the protective colloidal effect in urine, and hyaluronidase did not show an obvious increasing effect. It is obscure, however, that such an increasing effect of chondroitin sulfate is due to the chondroitin sulfate itself or some unknown substance in the metabolic process of chondroitin sulfate . The protective effect of neo-strong Minophagen C seems to be a direct protection for urinary salts , and glycyrrhizine particularly glycyrrhezic acid, above all other constituent elements of neostrong Minophagen C, seems most effective. 3) From the results of salt p rezipitated experiment, electrodes were inserted into urine, with or without addition of polytamin, neo-strong Minophagen C and its constituent components and chondroitin sulfate, it was recognized that the amount of prezipitated salts were decreased by the addition of these substances . Also in this experiment, the amount of prezipitated salts were increased with addition of salts or colon bacilli .