前立腺亜鉛代謝に関する実験的研究 第3編: 前立腺実験腫瘍について

Abstract

1) Male rats of the wistar strain, weighed about 70 gm s , were subjected to have injection of 0.1 ml. of 3% 20-Methylcholanthrene into the frontal lobe of the proststic gland. Among these rats, 52.7% of them developed proststic neoplasms, including 80% of squamous carcinoma, 15% of sarcoma and 5% of adenocarcinoma. 2) The uptake rate of 65Zn in the fro n tal lobe of the prostatic gland in 24 hours of administration was 1.5 cpm/mg in the control group, whereas it was 2 to 3 times higher than control in the neoplastic tissue. The highest uptake rate of 65Zn was seen in sarcoma with the subsequence in order of adenocarcinoma and squamous carcinoma. 3) The change of the amount of 65Zn in the neoplastic tissu e was slower than in the blood, and the biological half life was found to be 15-16 days. 4) In neoplastic group, the adrenal gland was foun d to be the only one organ which slowed increase of 65Zn uptake rate accompanied with increase of weight. No difference of uptake rate to the control group was found in blood, liver, pancreas, testicles, seminal vesicle and dorso-lateral lobe.