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タイトル: 尿路感染症に対するメタコリマイシンの使用経験
その他のタイトル: Use of methacolimycin for urinary tract infections
著者: 渡辺, 昌美  KAKEN_name
川村, 俊三  KAKEN_name
石崎, 充  KAKEN_name
著者名の別形: WATANABE, Masami
KAWAMURA, Shunzo
ISHIZAKI, Mitsuru
キーワード: Adolescent
Adult
Colistin/blood/therapeutic use/urine
Female
Humans
Male
Middle Aged
Urinary Tract Infections/drug therapy
発行日: Feb-1967
出版者: 泌尿器科紀要刊行会
誌名: 泌尿器科紀要
巻: 13
号: 2
開始ページ: 175
終了ページ: 181
抄録: Methacolimycin (each capsel contains 100 mg strength, 3 mil l i on units of colistin methanesulfonate sodium) was orally administered in order to determine its blood and urine concentrations. Then the drug was given to 26 patients with urinary tract infections to evatuate the clinical effectiveness. The results are summarized as follows. 1) The urinary concentration of this drug in patie n ts having normal renal function was the highest during 2 to 3 hours after oral administration and it decreased after 6 hours. In patients with renal function disturbance, however, the urinary concentration was lower than in patients with normal renal function although a sufficiently high blood concentration was achieved. 2) Among 26 cases given Methacolimycin, marked improvements of subjective symptoms and objective findings were noted in 12 cases. In addition other 7 cases showed some responses, so that a total of 19 cases was proved to be effective. In general, the effectiveness was less pronounced in cases with organic urinary tract changes than without changes. As the relation to the causal organisms, the drug was proved to have a relatively high effectiveness against E. coli and Proteus mirabilis while it had less effect against Staph. aureus and Stanh. enidermidis.
URI: http://hdl.handle.net/2433/113096
PubMed ID: 5624107
出現コレクション:Vol.13 No.2

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