尿路感染症に対するCephaloridineの使用経験

Abstract

Thirty-one patients with various urinary tract infec t ions were treated with Cephaloridine. A single dose of 500 mg was administered intramusculary for five to nine days and its results were evaluated. In seven cases of acute cystitis, Cephaloridine was highly effective and bacteriological cure was obtained in five of them. In twenty-four cases of various chronic urinary tract infections, Cephaloridine was effective in fifteen cases (bacteriological cure in four cases, improvement in eleven cases), but was not effective in the remaining nine cases. Bacteriological study reveale d that Cephaloridine was effective in the treatment of urinary tract infections caused by E. coli, Proteus, Klebsiella, Staphylococcus and Enterococcus, and was not effective in those caused by Pseudomonas. Cephaloridine sensi-disc test w as performed on 119 bacterial strains isolated from the patients with various urinary tract infections and was found to be highly sensitive to E. coli, Enterococcus and Staphylococcus, relatively sensitive to Proteus and Klebsiella, and resistant to Pseudomonas. Unpleasant side effects developed in two of the total sixty-one patients who were administered Cephaloridine at our hospital. The reactions were rather severe revealing allergic exanthema associated with facial edema, chill and dyspnea, but was subsided shortly after the administration of an anti-histamic drug.