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Title: ヒト膀胱平滑筋細胞の形態学的Phenotypeの検討
Other Titles: Phenotypic changes in human bladder smooth muscle cell
Authors: 松本, 成史  KAKEN_name
花井, 禎  KAKEN_name
栗田, 孝  KAKEN_name
秋山, 隆弘  KAKEN_name
Author's alias: Matsumoto, Seiji
Hanai, Tadashi
Kurita, Takashi
Akiyama, Takahiro
Keywords: Adolescent
Aged, 80 and over
Contractile Proteins/metabolism
Middle Aged
Muscle, Smooth/cytology
Prostatic Hyperplasia/pathology
Urinary Bladder/cytology
Urinary Bladder Diseases/genetics/pathology
Urinary Bladder Neoplasms/pathology
Urinary Bladder, Neurogenic/pathology
Issue Date: Dec-2003
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 49
Issue: 12
Start page: 715
End page: 719
Abstract: 1999~2000年までの2年間に膀胱疾患に対して手術加療され,膀胱の一部分,または全摘出した症例のうち,膀胱体部の標本を一部本研究に提供することに同意を得た15例(男11例,女4例,年齢7~82歳,平均52.1歳)を対象にした.基礎疾患は神経因性膀胱(NgB)2例,慢性腎不全6例,前立腺肥大症3例,膀胱癌(BT)3例,膀胱尿道逆流症1例であった.ヒト膀胱平滑筋細胞の形態学的phenotypeについて検討した結果,ヒト膀胱平滑筋細胞においても血管平滑筋細胞と同様にphenotypeという概念を用いて分類することが可能であった.膀胱において筋層内の線維化とphenotypeの比率に関連を認めなかった.また,NgBなどの病的膀胱には合成型phenotypeが優位で,収縮型から非収縮型へ膀胱平滑筋細胞のphenotypeが形質変換しており,このphenotypeの調節が排尿筋機能に重要な役割を果たしていると思われた.線維化や収縮能のマーカーと成り得る可能性が示唆された
Tissue specimens were resected from 15 patients (age 7 to 82, average 52.2 years old) with bladder diseases; i.e., 2 with neurogenic bladder, 6 recipients of kidney transplantation with defunctionalized bladder, 3 with benign prostatic hypertrophy, 3 with bladder cancer and 1 with vesicoureteral reflux. We investigated the phenotypic expression of the bladder smooth muscle cells with bladder diseases. The ratio of non-contractile to contractile phenotypes (nc/c ratio) showed a rising tendency with aging. The increase of nc/c ratio was especially notable with neurogenic bladder. Phenotypic expression was observed in human bladder smooth muscle cells as reported in vascular smooth muscle cells. Several bladder diseases cause a conversion of contractile smooth muscle cell phenotype from contractile type to non-contractile type, and this modulation of smooth muscle cell phenotype may play an important role in detrusor function.
PubMed ID: 14978953
Appears in Collections:Vol.49 No.12

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