膀胱原発小細胞癌の2例

Abstract

80歳男では, 膀胱鏡検査で後壁に中心がある大きい腫瘍を認め, 生検で小細胞癌と診断された.動注化学療法を行ったが, 8ヵ月後に多発肝転移で死亡した.80歳男では, 膀胱鏡検査で左側壁に腫瘍を認め, 生検で小細胞癌と判明した.放射線療法及び膀胱部分切除を行った.術後6ヵ月に再発の証拠はなく元気である

Small cell carcinoma of the urinary bladder is a rare entity, and is considered to be of neurosecretary origin. Its prognosis is generally poor even with aggressive therapy. In Japan, 19 cases of small cell carcinoma of the urinary bladder have been reported including our cases. We herein report two cases of small cell carcinoma of the urinary bladder. One patient was an 80-year-old male. Cystoscopy revealed a large tumor centered on the posterior wall of the urinary bladder. The biopsy specimen of the tumor revealed small cell carcinoma. Intraarterial infusion chemotherapy was performed. He died of multiple liver metastasis 8 months after chemotherapy. The other patient was a 80-year-old male. Cystoscopy revealed a bladder tumor on the left lateral wall. The biopsy specimen of the tumor revealed small cell carcinoma. Irradiation and partial cystectomy were performed. He has been well without any evidence of recurrence 6 months after surgery. Our cases and a review of the literature indicate that a multidisciplinary treatment may improve prognosis of small cell carcinoma of the urinary bladder.