アルガトロバン製剤によって治癒が促進したと考えられたFournier's gangreneの1例

Abstract

58歳糖尿病男性に発症したFournier's gangreneを経験した.早期診断にCTが有用であった.早期の外科的治療と抗菌剤の併用, ならびに血流改善を目的としたアルガトロバンの使用により, 良好な経過をたどり治癒した

A 58-year-old man was admitted to our hospital complaining of pain and marked swelling of scrotum and perineum. Physical and radiological examinations revealed gas-producing gangrenous changes involving the scrotum. Debridement was urgently carried out. Following the debridement under control of diabetes mellitus, antimicrobial agents and argatroban, a newly synthesized antithrombin medicine, were administered. Argatroban was used for the purpose of improving vascular insufficiency. Healthy granulation tissue was present five weeks later. Then surgical closure was carried out. Computed tomography was useful to make early diagnosis, and argatroban was thought to accelerate healing of the gangrene.