猪苓湯及び五苓散のヒト尿中蓚酸カルシウム結晶形成に及ぼす作用の検討

Abstract

1)猪苓湯投与前後で尿中パラメーターに有意な変化はみられなかったが, 五苓散投与により尿中マグネシウム排泄量が有意に増加した. 2)猪苓湯投与による蓚酸カルシウム結晶の平均粒径の変化に有意差は認められなかったが, 五苓散では投与後に蓚酸カルシウム結晶の平均粒径は有意に縮小した

The inhibitory effect of two kinds of Kampou medicine, Chorei-to and Gorei-san, on calcium oxalate crystallization in human urine, was examined. Chorei-to or Gorei-san was administered to 15 healthy male volunteers for three consecutive days under normal dietary conditions and 24-hour urine samples were collected before and after the administration. Urinary parameters including calcium, phosphorus, uric acid, oxalate and citrate were measured on each sample obtained. The inhibitory effect on calcium oxalate crystallization was examined using part of the collected 24-hour urine. There was no significant difference in urinary parameters before and after Chorei-to administration. Gorei-san administration significantly increased magnesium excretion in urine. A significant inhibitory effect on calcium oxalate crystallization in human urine was recognized when Gorei-san was administered, whereas Chorei-to had no inhibitory effect on calcium oxalate crystallization in urine.