Norfloxacin3日間連続投与後の前立腺組織内濃度について

Abstract

NFLX 3日間計1, 800 mg連続投与後のPを測定した.200 mg最終投与後約17時間でのPの値は0.05～0.65 μg/gで平均0.38±0.18 μg/gであった.200 mg最終投与後5.5時間でのPの値は0.23～1.63 μg/gで, 平均0.89±0.32 μg/gであった.P/Sはそれぞれ平均2.23±0.65および2.07±0.86であったことによりNFLXは血清よりも前立腺組織内に, 高濃度に残留していたといえる.200 mg最終投与後5.5時間の時点では, グラム陰性菌のほとんどすべての菌種のMICを大幅に上まわっており, グラム陽性菌の約半数の菌種のMICを上まわる濃度を保っていた

The penetration of norfloxacin into prostatic tissue was evaluated on 36 patients with benign prostatic hypertrophy. Norfloxacin was administered orally in a dose of 200 mg three times daily for 3 days preoperatively, blood samples were taken simultaneously at the time of tissue sampling. The patients were divided into 2 groups, groups 1 and 2. In group 1, tissue sampling was done after about 17 hours of final administration of the drug. The mean concentration of norfloxacin in prostatic tissue was 0.38 +/- 0.18 micrograms/g and 0.18 +/- 0.09 micrograms/ml in serum. In group 2, sampling was done after 5.5 hours of final administration. The mean concentration of norfloxacin in prostatic tissue was 0.89 +/- 0.32 micrograms/g and 0.49 +/- 0.25 micrograms/ml in serum.